Researchers at North Carolina State University’s College of Veterinary Medicine are warning that overuse and misuse of non-steroidal anti-inflammatory drugs (NSAIDs), such as bute, Banamine, ketoprofen and naproxen may cause gastrointestinal injury (stomach ulcers, and severe inflammation and injury of the colon otherwise known as colitis), kidney damage and even death in horses. These drugs are considered the cornerstone treatment for various maladies, most notably arthritis, laminitis and colic. But the researchers recommend, “The overall goal of pain management therapy should be to use these drugs at the lowest possible dose for the shortest time possible.” They go on to state that NSAIDs can be used successfully, but practical guidelines should be followed:

1. Avoid full doses of NSAIDs over prolonged periods of time.

2. Always ensure good hydration—dehydration contributes to the adverse effects of NSAIDs.

3. Pay close attention to the horse’s manure output; changes may be an early indication of gastrointestinal problems.

4. Monitor urine output. Excessive or minimal urination could be a sign of trouble with kidney function. Also watch urine color: Very dark or reddish urine needs to be discussed with your veterinarian immediately.

5. Consider time off from NSAID treatment. If you’re using bute on a daily basis to keep your horse comfortable, a “NSAID vacation” may help stave off GI tract and kidney damage.

6. Don’t use multiple pain medications unless directed by your veterinarian.

7. Diarrhea, colic or reduced appetite are warning signs that your horse may be experiencing NSAID complications. Call your veterinarian if any problems arise while your horse is on NSAID treatment.